Avoid fasting or missing meals by sticking to a regular eating schedule. It is present from birth, but any symptoms may not appear until ages 20 to 40. Gilbert's ( zhil-bairs) syndrome is a fairly common liver disorder that is present at birth, but usually only becomes apparent in the teens or early adulthood. Jaundice is a symptom for many serious health conditions, including: Read Next: How to Improve Liver Function in 6 Steps. 652 E Warner Rd Ste 107, Gilbert AZ 85296. Gilbert syndrome is an ignored clinical entity in many countries as only few studies investigated the frequency and the clinico-genetic . Ophthalmology 33 years experience. Both of these supplements work, in part, by their effect on the Farnesoid X receptors (FXRs). Oxford/AstraZeneca: "liver disease" excluded (except Gilbert syndrome), "alcohol and drug dependencyinjecting drug abuse in the 5 years preceding enrolment" excluded. Eat a healthy diet. Staying hydrated can help keep Gilbert's syndrome symptoms in check. The medical evidence shows that Gilberts syndrome is a disability caused by a hereditary deficiency of an enzymes. Below is a list of common natural remedies used to treat or reduce the symptoms of Gilbert+Syndrome. Our liver stores important vitamins and nutrients from the food we eat and stocks them up for when we need them later. Does apple cider vinegar help your liver? Gilbert's syndrome does not lead to liver disease, but eating a healthy and balanced diet can help keep your liver healthy and prevent ill effects. Appointment scheduling. Irritable bowel syndrome (IBS) Any inflammatory bowel disease (IBD) If you are unsure if a Vitamin C flush is appropriate for you, please speak to your healthcare professional. Based on 30 member reports. Ranked #5 most tried. Yellowing of the skin and whites of the eyes is one of the symptoms of Gilberts syndrome. Gilbert's syndrome is an inherited condition that is present from birth. We also use third-party cookies that help us analyze and understand how you use this website. These steps include: Make sure your health care providers know you have Gilbert syndrome. In addition, because excessive alcohol depletes glutathione, milk thistle can aid in protecting the livers of alcoholics or those recovering from alcohol abuse. However, for some people. Exercise, meditation, and music listening may be beneficial. Gilbert Center for Family Medicine. A variety of vitamins for Gilbert syndrome and nutrients are necessary for liver health, usually obtained by eating a balanced, nutritious diet. Can Gilberts syndrome make you feel sick? Speak with your doctor about the ongoing progress and results of these trials to get the most up-to-date information on new treatments. Keep your liver healthy by eating high-fiber fruits and veggies. 11th ed. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. links and notes that might help people with Gilberts Syndrome. Bleeding in the stomach can make you vomit. This content does not have an English version. (7). It is advised to not eat eggs because they are hard to digest for the livers. Specifically, people with the syndrome who also have another condition that increases bilirubin levels, such as sickle cell anemia, run a higher risk of getting gallstones. Its not true to say that lemon water is good for you. Moreover, studies have shown that it can increase glutathione concentration by up to 35%. Vitality, Muscle Health, Healthy Aging 120ct/150mg, Zenwise Digestive Enzymes Plus Prebiotics & Probiotics Supplement, 180 Servings, Vegan Formula for Better Digestion & Lactose Absorption with Amylase & Bromelain, 2 Month Supply. There was a significant increase in total bilirubin levels in males who were fast compared to males who were slow. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Artichoke leaf extract is still often used before big, fatty meals since it is supposed to help break up lipids in the diet. A background of Gilberts syndrome led to the diagnosis of a deficiency of vitamins B12 and B. It is possible to see blood in the urine or stool. However, if you have liver disease, you should see a doctor before taking any supplements since large amounts of particular nutrients might be dangerous in your case. GS diagnosis should be considered in patients with chronic elevation of unconjugated . This substance is removed from the body only after it undergoes a chemical reaction in . The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Yoga, meditation, prayer, daily exercise, music therapy, certain essential oils and even just taking a walk outdoors may help reduce your stress. It can cause allergic reactions like itching, headaches, and joint pain. Vitamin D is a supplement treatment often tried in the Gilbert syndrome community. As a result, excess . [1] Under normal circumstances, approximately 95% of bilirubin is unconjugated. Considering taking a vitamin or supplement to treat Gilbert+Syndrome? If you have jaundice, make an appointment with your physician as it can be the result of many health conditions, including Gilberts syndrome. The findings suggest that mothers should take vitamins to help their babies. Stress may even increase the risk of a certain type of liver cancer called hepatocellular carcinoma. The milk products are made from cheese, butter, buttermilk, and margarines. are clickable links to medically peer-reviewed studies. Gilbert's syndrome is a common harmless liver condition in which the liver does not correctly process a substance called bilirubin. Often this is expressed via symptoms like nausea, food intolerances, bloating and . Its a good idea to not drink alcohol. If you are just starting to exercise, walking, yoga, swimming and HIIT workouts are great ways to improve your overall fitness and health. Because L-cysteine is only available in trace levels in food, some people may benefit from taking an N-Acetyl Cysteine supplement. When increasing the fiber in your diet, do so slowly to prevent gas and abdominal pain. Bilirubin is the byproduct of the breakdown of red blood cells. Reduces liver damage from excessive alcohol. It affects both sexes, but is most common in men. Where does bilirubin originate, answer the liver. According to the Mayo Clinic, Gilbert's (pronounced zheel-BAYRS) syndrome is a harmless condition in which the liver doesn't properly process and excrete bilirubin, the pigment produced by the breakdown of red blood cells. Among these vital roles include delivering glucose to the brain, fighting infections, and storing nutrients. Gilbert's syndrome occurs due to the reduced activity of a liver enzyme that makes the liver less capable of processing bilirubin. People with the condition have a mild increase in the level of a yellow pigment in the blood called bilirubin ( billy-roo-bin ). Milk thistle should not be taken if you have an allergy to daisies, ragweed, or other flowers. Stress, strain, dehydration, fast, infections, and exposure to cold are some of the factors that can affect Bilirubin levels. . Choline - Assists with the digestion of fat. Is there any medicine to reduce bilirubin? Numerous other herbs and supplements have shown a bit of promise in test tube . There are usually short-lived episodes of the disease. 2005 - 2019 WebMD LLC. 90 Capsules, DIM Supplement 200mg DIM Diindolylmethane Plus BioPerine 60-Day Supply of DIM for Estrogen Balance, Hormone Menopause Relief, Acne Treatment, PCOS, Bodybuilding, Onnit Alpha Brain Premium Nootropic Brain Supplement, 30 Count, for Men & Women Caffeine-Free Focus Capsules for Concentration, Brain & Memory Support Brain Booster Cats Claw, Bacopa, Oat Straw, Multi Award Winning Patented NAD+ Booster Supplement More Efficient Than NMN Nicotinamide Riboside for Cellular Energy Metabolism & Repair. Other than the resulting change in skin color, Gilbert's syndrome is relatively benign. Do your energy levels plummet once the summer months are over? Does Gilbert syndrome affect bowel movements? Some things can cause high levels, such as medications, exercise, or certain foods. Gilbert syndrome is a genetic condition in which a person has high levels of a substance in the body called bilirubin. It is a benign liver condition that rarely causes symptoms, requires no treatment . Since weight reduction is known to reduce several cardiovascular risk factors, its important to note that each one percent decrease in weight loss is associated with a linear increase in serum bilirubin concentration. Gilbert syndrome is a harmless genetic condition in which the liver does not process bilirubin effectively, causing a buildup in the body. 4. It promotes the regeneration of new liver cells which replace old and damaged one. 2005 - 2023 WebMD LLC. Vitamin E - Formation of gallstones can . Bilirubin is a major breakdown product of hemoglobin, which is the pigment that carries oxygen in the red blood cells. Those with gallbladder problems, bleeding disorders, diabetes, gastroesophageal reflux disease (GERD), infertility, iron deficiency, liver disease, hormone-sensitive conditions and arrhythmia are some of the people who should not takeTurmeric. Without the help of lemon water, you already have a body that is free of toxins. It would be best if you avoided highly low-calorie diets. Its good to relieve the symptoms of jaundice by eating a lot of spinach. This is a genetic disease that can be passed from either mother or father. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. If you drink, consider quitting. Qunol Ultra CoQ10 100mg, 3x Better Absorption, Patented Water and Fat Soluble Natural Supplement Form of Coenzyme Q10, Antioxidant for Heart Health, 120 Count Softgels, Probiotics 60 Billion CFU Probiotics for Women, Probiotics for Men and Adults, Natural, Shelf Stable Probiotic Supplement with Organic Prebiotic, Acidophilus Probiotic, Organic Ashwagandha Capsules High Potency 1300 mg: Ultimate Natural Sleep Support, Immune Support, Focus, and Energy Supplement with Black Pepper for Wellbeing and Vitality, Glucosamine with Chondroitin Turmeric MSM Boswellia. (480) 539-8680. In addition to water, you can meet your fluid needs by drinking 100 percent fruit or vegetable juice, unsweetened decaf tea, fat-free milk or fortified soy milk. Other symptoms that suggest Gilbert syndrome as well as a number of other liver conditions include dark urine and abdominal pain. In addition, women with certain hormone conditions, hormone-sensitive cancers and breast cancer should talk to their doctor before consuming large amounts of grapefruit as it increases certain hormone levels. How high is bilirubin in Gilberts syndrome? Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, 6 Minutes of Exercise May Protect Brain From Alzheimer's, 'Disturbing' Rate of Adverse Events During Hospital Stays. https://www.uptodate.com/contents/search. The cookie is used to store the user consent for the cookies in the category "Other. Gilbert's Syndrome and Liver Function. Most people think of bacteria within the body as a cause of Having trouble pooping? It is harmless but can cause jaundice (yellowing of the whites of the eyes). However, you may visit "Cookie Settings" to provide a controlled consent. Dark yellow or orange is the color of the bilebin in the urine. Gilbert's syndrome is found among people who take Vitamin d, especially for people who are female, 30-39 old. There is a. No supplements or herbs are needed to address this condition . Burdock herb is a detoxifier as well as blood purifier. You should make a number of changes to your diet if you have elevated levels of bilirubin. All rights reserved. A regular eating plan usually includes three meals plus two to three snacks daily. However, if you want to take the herb itself, a tablespoon of ground milk thistle can be sprinkled over breakfast cereal once daily. The doctor needs to distinguish between the benign disorder and the more serious causes of elevated bilirubin levels. Vitamins For Gilbert Syndrome. Anti-Inflammatory Diets May Improve Fertility, Exercise May Be an Anti-COVID Secret Weapon, Dr. Whyte's Book: Take Control of Your Diabetes Risk, Street Medicine Reaches People Where They Live, Health News and Information, Delivered to Your Inbox, IMPORTANT information about user generated content. Gilbert's syndrome. Gilbert syndrome - May manifest only as jaundice on clinical examination; at least 30% of patients with Gilbert syndrome are asymptomatic, although nonspecific symptoms, such as abdominal cramps, fatigue, and malaise, are common . Make a donation. Is this an emergency? If you have high levels of bilirubin, its possible youre not functioning properly. https://liverfoundation.org/for-patients/about-the-liver/diseases-of-the-liver/gilbert-syndrome/. Avoid infections and dehydration zinc is sometimes . Follow the links to read common uses, side effects, dosage details and user reviews for the vitamins and supplements listed below. Which type of therapy can increase bilirubin levels? Dont forget to take a lot of liquids like fruit juices, water, electrolyte water, and coconut water. How long does it take to lower bilirubin? Accessed June 1, 2022. Some people with Gilbert's syndrome choose to eat a higher-fat paleo or keto-style diet. Natural treatments focus on ways to boost liver health while preventing poor sleep, stress, dehydration or an illness from triggering jaundice. What foods should you avoid with Gilberts syndrome? (1). Gilbert's Syndrome affects 5% of the adult population, is benign and is a congenital/hereditary liver disorder characterized by a mild, fluctuating increase in serum bilirubin, the yellow pigment excreted by the liver into bile. It is possible that a heavy workout lowers inflammation. . Most nuts and legumes are rich in antioxidants, including vitamin E and phenolic acid. This site complies with the HONcode standard for trustworthy health information: verify here. "When you don't eat for maybe 12 to 24 hours, this increases the bilirubin mobilization from the fat tissue, which can go into the blood, and [in people with Gilbert's syndrome] trigger an episode of jaundice," Dr. Adhami explains. It is a good idea to eat a diet that is healthy. Look for high fiber foods, such as oatmeal, broccoli . This leads to greater than normal levels of bilirubin circulating in the bloodstream, which can cause yellowing of the skin and eyes. A report in the April 2015 issue of American Journal of Medical Case Reports claimed success with this type of diet, but it only reported on one patient's experience, and wider recommendations can't be made. In a cup of hot water, add a teaspoon of burdock root powder and let it steep for 10 minutes. It is often combined with other herbs and nutrients, such as dandelion, choline, methionine and inositol. Summary of effects on the body from Gilbert's Syndrome. Could the medications I'm taking for other conditions worsen Gilbert syndrome? Avoid any nutritional supplements containing high doses of vitamin A, niacin, cod or halibut liver oil, or vitamin D. Gilbert's syndrome is a genetic condition that runs in families. It may be able to prevent damage to theLiver. There are many great choices of vegetables. Stay hydrated. The herb blooms from June to August, and the shiny black seeds used for medicinal purposes are collected at the end of the summer. This gene is responsible for creating the liver enzyme that converts and excretes bilirubin from the body. (1). This genetic disease occurs when you inherit a mutated gene, the UGT1A1. Additionally, Gilberts syndrome and alcohol intolerance are a concern. However, treatment is not required since this liver illness does not create significant issues. In that case, you must think about taking a high-quality multivitamin and mineral supplement to ensure that your liver, as well as the rest of your body, is properly maintained. For people with Gilbert's Syndrome lack of energy is a really commonly reported symptom. Nutritional Supplements- any nutritional supplement that has the high concentration of Vitamin A, niacin, vitamin D or cod or halibut liver oil over recommended dose must be avoided as they cannot be completely metabolized by the liver. There is some evidence that milk thistle can be used to treat chronic hepatitis, which can be caused by alcohol abuse, as well as other diseases. Among the benefits of milk thistle is its ability to fortify the liver, one of the bodys most important organs. Studies have shown that lemon has a greater effect on the production of enzymes in the body than other foods. Necessary cookies are absolutely essential for the website to function properly. The results of the smaller study of 20 patients with chronic active hepatitis showed that the milk thistle group had lower levels of transaminase, bilirubin, and gamma-glutamyl transpeptidase than the placebo group. In fact, 30% of the people who have this condition may not show any symptoms. study, there was a higher incidence of liver disease in people who were deficient in vitamins D and D3. It may be useful for endometriosis (the most common cause of infertility in women) because it helps the liver to process the hormone oestrogen, which at high levels can make pain and other symptoms worse. A. Gilbert's (pronounced jeel-bears) syndrome was named after one of the French doctors who first described it. You also have the option to opt-out of these cookies. People with Gilbert's syndrome don't produce enough liver enzymes to keep bilirubin at a normal level. Supports Occasional Joint Discomfort Relief. The doctor has told us that it doesn't require any medical treatment. (28). For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Stress on the liver is caused by chemicals in coffee, herbs, spices, alcohol, tea, chocolate, and almost all frozen preserved 'ready meals'. But opting out of some of these cookies may affect your browsing experience. These cookies track visitors across websites and collect information to provide customized ads. There's nothing complicated about a diet that will keep symptoms in check: avoid fasting, eat healthy and stay hydrated. . There is no one-size-fits-all answer to this question, as the best vitamins for Gilbert syndrome may vary depending on the individual's unique situation and health condition. Beet root - Thins bile, and this helps to prevent formation of gallstones. Follow the links to read common uses, side effects, dosage details and read user reviews for the drugs listed below. Normally, when red blood cells reach the end of their life (after about 120 days), haemoglobin, the red pigment that carries oxygen in the blood, breaks down . Correct fat malabsorptionif this is an issue and check fat soluble vitamins ( your poo may tell you this if it is slimy, fatty or floats). Considering taking a vitamin or supplement to treat Gilbert+Syndrome? (29). These supplements are: ( 2) Milk thistle. Because of this, the bilirubin accumulates in the bloodstream, which results in a condition named hyperbilirubinemia. Clinical trial of vitamin C. Letter to the editor. If you are suffering from dry eye syndrome, be sure to consult with your doctor about the potential benefits and side effects of beginning a vitamin supplement. Stick to eating nutrient-dense meals and avoid processed foods. being sick or having an infection. Eating regularly not only helps control the symptoms associated with Gilbert's syndrome but also helps keep energy levels up and aids in hunger control. Below is a list of common natural remedies used to treat or reduce the symptoms of gilbert syndrome. You can read more bout how exactly GS affects your liver function HERE. It has been reported as tried by 3% of the members. N-Acetyl Cysteine is a dietary supplement derived from the amino acid L-cysteine and is required to form glutathione, one of the bodys most potent antioxidants. fasting, skipping meals, or not having enough food. It does not store any personal data. What causes Gilberts syndrome to flare up? You may occasionally have jaundice, which usually resolves on its on with no ill effects. Advertising revenue supports our not-for-profit mission. In a clinical review published in the World Journal of Gastroenterology, researchers identified a variety of foods and natural products that have liver-protective effects. Manage stress. (5), The British Liver Trust recommends that people with Gilberts syndrome avoid fatty and sugary foods. Predisposition to gallstones and gallbladder issues (more on this below). In people with Gilbert's syndrome, the bilirubin is typically mildly elevated and often fluctuates. It breaks down the toxins in the body and leaves them in the urine. We use cookies to ensure that we give you the best experience on our website. The information provided on gilbertssyndrome.org.uk is of a general nature and cannot substitute for the advice of a medical professional. Gilbert's disease. Men need 30 to 38 grams of fiber a day and women 21 to 25 grams a day. . Posted 4 years ago. This condition is a common inherited illness that affects how the liver processes bilirubin -- a yellowish pigment made in the liver and a . . It is a good idea to eat a diet that is healthy. absorb fat soluble vitamins A, D, E and K and produce melatonin . The high bioavailability forms of turmeric were linked to several cases of injury and may have been the cause of the outbreak of acute hepatitis in Italy. It is not a serious disease. Treats liver disorders such as cirrhosis and hepatitis. In the Skaaby et al. Is there anything I can do to maintain a low bilirubin level? It then follows that we should always try to reduce stress on the liver. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc. "Gilbert's syndrome isn't a disease and isn't life-limiting or altering, but it can complicate other conditions," Dr. Adhami says. The number of Americans who are overweight is on the rise, and research at Oregon State University shows that one particular type of Omega 3 can help. Limit yourself to a few drinks per month if you drink too much. Resistance or strength training can be used to improve the health of your body. As grapefruit and grapefruit juice are known to interact with a number medications, including those for high blood pressure, sedation and many other conditions, check with your doctor before adding grapefruit or grapefruit juice to your diet. Combining Gilberts syndrome with alcohol consumption isnt recommended. This content does not have an Arabic version. It was found that an increase in the concentration of bilirubin is caused by fasting. It occurs after the first week of life. In this episode, Nutritionist Maria Allerton (ne Shaflender) talks to us in . . This cookie is set by GDPR Cookie Consent plugin. Clemson Cooperative Extension: Fluid Needs. This website uses cookies to improve your experience while you navigate through the website. In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. Jaundice episodes, as well as any accompanying symptoms, are generally brief and disappear in time. Correct fat malabsorptionif this is an issue and check fat soluble vitamins ( your poo may tell you this if it is slimy, fatty or floats). menstruating. This cookie is set by GDPR Cookie Consent plugin. Does Gilbert's Syndrome cause fatigue? The most common and it is considered rare is jaundice. Master your immunity with Gilberts Syndrome. Because Gilberts syndrome impacts how your body processes certain drugs, each doctor you see should be mindful of your condition. Supplement for Back, Knees, Hands. Gilberts (zheel-BAYRS) syndrome is a harmless condition in which the bile duct doesnt properly process bilirubin. Melanoma: Vitamin D supplements linked to reduced . Analytical cookies are used to understand how visitors interact with the website. Helps to clear psoriasis. Gilbert's syndrome and unconjugated hyperbilirubinemia due to bilirubin overproduction. Is my bilirubin level significantly elevated? not eating for a long period of time. Gilbert syndrome does not require treatment and . Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, IMPORTANT information about user generated content. In Gilberts syndrome, specific life experiences, such as stress, may cause bouts of elevated bilirubin levels, resulting in jaundice. Making sure you get enough to drink is also important when you're upping your fiber intake. If you continue to use this site we will assume that you are happy with it. . (3), Some patients report mild and vague symptoms, but researchers dont believe that they are caused by excess bilirubin in the blood but may be a coincidence or caused by other conditions. If you want to start the day with a dash of pepper and a glass of warm water, you need to consume half aTurmeric with a dash of pepper and a glass of warm water. Eggs are hard to digest due to their high amount of protein. However, some suggested vitamins for Gilbert syndrome include vitamin B6, magnesium, and milk thistle. As an Amazon Associate I earn from qualifying purchases.Privacy Policy | Affiliate Disclosure. Red blood cells are broken down to produce Bilirubin. Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Milk thistle is one of the most extensively studied and document herbs in use today. The herb also reduces the inflammation and may slow the skin-cell proliferation associated with psoriasis. . The underlying cause is the lack of a specific liver enzyme to convert un-conjugated bilirubin to conjugated bilirubin due to the mutation in the UGT1A1 gene. Gilbert's syndrome is an inherited (genetic) liver disorder that affects the body's ability to process bilirubin. It is important for individuals to take vitamins E, C, and B on a regular basis. Guidelines for use : Milk thistle extract seems most effective when taken between meals. Every doctor you visit needs to know that you have Gilberts syndrome because it affects how your body processes certain drugs. This condition is not life-threatening, and generally conventional Gilberts syndrome treatment is focused on keeping the liver healthy. Reduces liver damage from excessive alcohol. Suppose your diet isnt always as healthy as it seems. Certain herbal supplements including cranberry, gingko biloba, hawthorn, noni, soy, grape seed, milk thistle . Your health care provider may suspect Gilbert syndrome if you have unexplained jaundice or if the level of bilirubin is elevated in your blood. Clinical history, physical examination, and blood test are some of the things that can be used to make a diagnosis. Moreover, Gilberts syndrome may go undetected until it is discovered by chance, such as when a blood test reveals increased bilirubin levels. Stress, strain, dehydration, fast, infections, and exposure to cold are some of the factors that can affect Bilirubin levels. Generally speaking, this condition is considered harmless and is associated with a normal life expectancy. are clickable links to these studies. Alcohol should be . Paracetamol- Gilbert syndrome shows the greatest toxicity of paracetamol after an overdose. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Gilbert's Syndrome is the genetic disfunction of the UGT1A1 gene that affects the removal of bilirubin from the body. In an article published in World Journal of Gastroenterology, researchers indicate that oily fish, fish oil, coffee and nuts are associated with better liver health. There is also some indication that it may aid with liver support. Women who are pregnant and are going to have surgery shouldnt use the drug. The bile is made up of bilirubin which is a yellow color. Aerobic exercise training has a beneficial effect on body composition. Irritable bowel syndrome, otherwise known as IBS, can cause a lot of stress, pain, and gastrointestinal symptoms such as bloating and cramping. All rights reserved. Retinoids (Vitamin A) - Vitamin A supplements inhibit the UGT enzyme, so high-doses are not recommended.